What makes our
product different?
Vocalise™ is not an everyday vitamin. It is not designed to get you onto a subscription. It is formulated for periods of high vocal demand — the back-to-back performance run, the intensive teaching week, the audition season that pushes your voice to its limit.
Every ingredient is dosed for maximum clinical efficacy. Not proprietary blends designed to hide underdosing. Not filler ingredients added for marketing copy. A tried and true formula built around published ENT and sports medicine research — ingredients that have been studied in human clinical trials and shown to actually make a difference.
Pineapple stem (2,500 GDU/g)
Bromelain is a mixture of cysteine proteases extracted from pineapple stem. Its therapeutic relevance in vocal health lies in three documented mechanisms: inhibition of prostaglandin E2 and COX-2 activity (the same inflammatory pathway targeted by NSAIDs), reduction of tissue edema through fibrinolytic and kinin-modulating activity, and mucolytic action that supports mucus clearance in the upper respiratory tract.
For professional voice users, the most relevant application is post-performance recovery. Heavy vocal use causes mechanical stress on the vocal folds, triggering a localized inflammatory response and micro-edema that compromises phonation quality and range. Bromelain's anti-edematous mechanism directly addresses this — and unlike NSAIDs, it does so without the gastric risk profile.
The 500 mg dose in Vocalise™ reflects the range used in clinical studies demonstrating systemic anti-inflammatory effects when taken between meals on an empty stomach, allowing intestinal absorption rather than digestive activity.
Papaya fruit (100 TU/mg)
Papain is a cysteine endopeptidase that, when ingested in a fasted state and absorbed intestinally, acts systemically to degrade inflammatory protein matrices and modulate immune response. Published research in recreational athletes demonstrates that oral protease supplementation including papain significantly accelerates recovery from exercise-induced muscle damage — a mechanism directly analogous to soft tissue stress from vocal use.
The analgesic properties of papain operate through inhibition of bradykinin — a key mediator of pain and inflammation at sites of tissue damage. For voice users experiencing laryngeal discomfort or post-performance throat inflammation, this mechanism is clinically relevant.
Papain works synergistically with bromelain in the Vocalise™ formula. Together, these two proteolytic enzymes provide broader protease coverage across inflammatory protein substrates than either would achieve alone.
Serratia marcescens E-15
Serrapeptase (serratiopeptidase) is a serine protease originally isolated from Serratia bacteria and it is the most ENT-specific enzyme in the Vocalise™ formula — and the most directly evidence-backed ingredient for vocal health applications.
The Mazzone et al. 1990 multicenter double-blind RCT enrolled 193 patients with acute and chronic otorhinolaryngological disorders. Serrapeptase demonstrated statistically significant reductions in pain, swelling, and secretion viscosity compared to placebo — across conditions including laryngitis, pharyngitis, sinusitis, and tonsillitis. These are the exact pathological presentations most relevant to professional voice users under heavy demand.
Serrapeptase's fibrinolytic activity is clinically significant: it selectively degrades non-living fibrin and inflammatory protein matrices without affecting healthy tissue, clearing the post-inflammatory debris that contributes to prolonged vocal fold swelling and stiffness after heavy use.
At 20 mg (120,000 SPU), Vocalise™ delivers serrapeptase at the dose range studied in published clinical trials.
100% pure turmeric extract
Curcumin is the primary bioactive curcuminoid in turmeric and one of the most extensively studied natural anti-inflammatory compounds. Its mechanisms are well-characterized: inhibition of NF-κB signaling, suppression of COX-2 and 5-LOX enzyme activity, and downregulation of pro-inflammatory cytokines including TNF-α and IL-6. The longstanding clinical limitation of curcumin has been poor bioavailability — standard curcumin extracts are rapidly metabolized and minimally absorbed, limiting their systemic therapeutic effect.
BCM-95® (CurcuGreen®) addresses this through a fundamentally different approach than phosphatidylcholine-based phytosomes. Rather than complexing curcumin with a carrier, BCM-95® retains the naturally occurring turmeric essential oil — specifically enriched to 45% ar-turmerone — alongside the curcuminoid complex. Ar-turmerone is a sesquiterpene ketone with its own documented anti-inflammatory and neuroprotective activity, and published pharmacokinetic research demonstrates that this whole-turmeric approach significantly enhances curcuminoid absorption compared to standard curcumin extracts.
Because BCM-95® is derived entirely from the turmeric rhizome with no synthetic carriers or excipients, it represents 100% pure turmeric — the full-spectrum bioactive profile of the plant rather than an isolated fraction. This is a meaningful distinction for a formula built around clinical transparency.
In the context of Vocalise™, BCM-95® provides the sustained systemic anti-inflammatory foundation that complements the acute-acting proteolytic enzymes — particularly relevant for voice professionals in extended performance seasons where chronic low-grade laryngeal inflammation accumulates over time.*
Vitamin C (ascorbic acid) at 48 mg (53% DV) serves a structural role in the Vocalise™ formula. Collagen is the primary structural protein of the vocal folds, subglottic tissue, and laryngeal mucosa. Vitamin C is an essential cofactor for prolyl and lysyl hydroxylase — the enzymes responsible for collagen cross-linking and stability. Without adequate ascorbate, collagen synthesis is impaired and connective tissue integrity deteriorates.
For professional voice users, the structural integrity of the vocal folds is the physical foundation of everything. Published research confirms Vitamin C's role in supporting both collagen synthesis and the oxidative stress response following musculoskeletal tissue demand — making it a clinically relevant addition to a formula designed for high-performance vocal use.
Vocalise™ vs.
Typical NSAIDs
Voice professionals have historically reached for NSAIDs like ibuprofen or naproxen to manage vocal fold inflammation. Below is a general comparison of the approaches — for informational purposes only.
| Consideration | Vocalise™ (Dietary Supplement) | Typical NSAID (e.g. Ibuprofen) |
|---|---|---|
| Primary Mechanism |
Multi-pathway enzyme activity Proteolytic enzymes (Bromelain, Papain, Serrapeptase) act on inflammatory protein matrices and support fibrinolysis. BCM-95® (CurcuGreen®) inhibits NF-κB, COX-2, and 5-LOX signaling via 100% pure turmeric curcuminoid complex. |
COX-1 and COX-2 inhibition Non-selective inhibition of cyclooxygenase enzymes reduces prostaglandin synthesis broadly across the body. |
| Gastrointestinal Profile |
Gastro-resistant enteric coating Enteric coating bypasses stomach — no direct gastric contact. Proteolytic enzymes are absorbed intestinally rather than acting in the stomach. |
Known GI risk profile COX-1 inhibition reduces protective prostaglandins in the gastric lining. Regular NSAID use is associated with gastric irritation, ulceration, and GI bleeding risk. |
| Vocal Fold Specificity |
ENT-targeted ingredients Serrapeptase has a multicenter RCT specifically in otorhinolaryngological patients — the only ingredient in this formula with ENT-specific clinical trial data. |
General anti-inflammatory Broad systemic anti-inflammatory effect. Not studied specifically for vocal fold or laryngeal tissue applications. |
| Mucosal Support |
Active mucosal support Serrapeptase reduces mucus viscosity and supports secretion clearance — with multicenter RCT data confirming significant reductions in secretion viscosity in ENT patients. |
No mucosal support NSAIDs do not support mucosal hydration or secretion management. Some evidence suggests drying effects on mucous membranes. |
| Structural Support |
Collagen synthesis support Vitamin C (53% DV) is an essential cofactor for collagen cross-linking — directly relevant to vocal fold tissue integrity and recovery. |
No structural support NSAIDs do not contribute to collagen synthesis or connective tissue repair. |
| Cardiovascular Considerations |
No known cardiovascular risk No cardiovascular contraindications associated with the ingredients in Vocalise™ at the doses used. |
Established cardiovascular risk Regular NSAID use — particularly COX-2 selective inhibitors — carries established cardiovascular risk, including increased risk of myocardial infarction and stroke with prolonged use. |
| Use Case Fit |
Designed for vocal performance demand Formulated specifically for periods of high vocal use: performance runs, audition seasons, intensive teaching schedules. |
General pain and inflammation Indicated for general pain relief, fever, and inflammation. Not formulated with voice professionals or vocal tissue in mind. |
| Regulatory Status |
Dietary supplement (FDA regulated) Regulated under DSHEA. Not FDA-approved to treat, diagnose, cure, or prevent any disease. |
FDA-approved OTC/Rx drug FDA-approved with specific indicated uses, contraindications, and dosing guidelines. Consult a physician or pharmacist. |
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Vocalise™ is a dietary supplement, not a drug. The research cited on this page refers to the individual ingredients at the doses studied; results may vary. Always consult a healthcare professional before beginning any supplement regimen.